臍帶膜幹細胞潛在的治療應用
時至今日,已經有超過 1000項臨床試驗發掘間質幹細胞的潛力,至今試驗結果令人鼓舞。幹細胞療法已被證實安全及有效協助修復由中風及心臟病造成的損傷。間質幹細胞也可結合造血幹細胞進行治療,幫助加快造血幹細胞植入,並協助減少移植時出現免疫系統併發症。
雖然有證據顯示間質幹細胞可分化成某些上皮細胞(非幹細胞),但間質幹細胞絕不可能轉化成上皮幹細胞。上皮幹細胞和上皮細胞的分別,在於上皮幹細胞可因應不同需要分化成特定的上皮細胞,如:皮膚、角膜、腸的軟組織等,每一種上皮細胞均是從上皮幹細胞經特定的終極轉化過程而形成,沒有能力再進一步按需要轉化成其他上皮細胞。因此,間質幹細胞和上皮幹細胞是不可互相替代的。
間質幹細胞潛在的治療應用5
- 心血管疾病(例如:心肌修復)
- 骨科應用(骨關節炎, 軟骨和肌腱修復)
- 肺纖維化1
- 中風2,3
- 新冠肺炎22
- 神經退化性疾病:
- 阿茲海默症
- 帕金森氏症
- 發展障礙:
- 自閉症譜系障礙 (ASD)4,5,6
- 腦性麻痺與癱瘓
- 整體發展遲緩
- 脊髓損傷7
- 肝衰竭的肝臟再生8,9,10
- 縮短幹細胞被受贈者接受的時間11
- 減少免疫系統併發症11
- 新冠肺炎22
- 抗宿主疾病(GvHD)移植排斥作用13
- 糖尿病:一型和二型14
- 愛滋病15
- 克羅恩病16
1Chuang HM, Shih TE, Lu KY, et al. Mesenchymal Stem Cell Therapy of Pulmonary Fibrosis: Improvement with Target Combination. Cell Transplant. 2018;27(11): 15811587. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299195/
2 Wang F, Tang H, Zhu J, Zhang JH. Transplanting Mesenchymal Stem Cells for Treatment of Ischemic Stroke. Cell Transplant. 2018;27(12):1825-1834 https://www.ncbi.nlm.nih.gov/pubmed/30251564
3 Xue P, Wang M, Yan G. Mesenchymal stem cell transplantation as an effective treatment strategy for ischemic stroke in asia: a meta-analysis of controlled trials. Ther Clin Risk Manag. 2018; 14: 909928. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5957058/
4 Shane, et al. Do the Stem Cells Really Work with Autism Spectrum Disorders Associated with Neuro-Immune Interaction? Autism Open Access. 2015; 5(3) https://www.longdom.org/open-access/do-the-stem-cells-really-work-with-autism-spectrum-disorders-associatedwith-neuroimmune-interaction-2165-7890-1000151.pdf
5 Liu Q, Chen MX, Sun L, et al. Rational use of mesenchymal stem cells in the treatment of autism spectrum disorders. World J Stem Cells. 2019; 11(2): 5572. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397804/
6 Siniscalco D, Kannan S, Semprn-Hern¡ndez N, et al. Stem cell therapy in autism: recent insights. Stem Cells Cloning. 2018; 11: 5567. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204871/
7 Xu P, Yang X. The Efficacy and Safety of Mesenchymal Stem Cell Transplantation for Spinal Cord Injury Patients: A Meta-Analysis and Systematic Review. Cell Transplant. 2019; 28(1): 3646. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322141/
8 Alfaifi M, Eom YW, Newsome PN, et al. Mesenchymal stromal cell therapy for liver diseases. J Hepatol. 2018;68(6):1272-1285. https://www.ncbi.nlm.nih.gov/pubmed/29425678
9 Maria P. de Miguel, I. Prieto, et al. Mesenchymal Stem Cells for Liver Regeneration in Liver Failure: From Experimental Models to Clinical Trials. Stem Cells International. 2019:3945672 https://www.hindawi.com/journals/sci/2019/3945672/
10 Wang YH, Wu DB, Chen B, et al. Progress in mesenchymal stem cellâÂÂbased therapy for acute liver failure. Stem Cell Research & Therapy. 2018;9(1):227 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109312/
11 Crippa S, Bernardo ME. Mesenchymal Stromal Cells: Role in the BM Niche and in the Support of Hematopoietic Stem Cell Transplantation. HemaSphere. 2018;2:6. https://journals.lww.com/hemasphere/Fulltext/2018/12000/Mesenchymal_Stromal_Cells__Role_in_the_BM_Niche.5.aspx
12 Damien P, Allan DS. Regenerative Therapy and Immune Modulation Using Umbilical Cord Blood-Derived Cells. Biol Blood Marrow Transplant. 2015;21(9):1545-54. https://www.bbmt.org/article/S1083-8791(15)00379-1/pdf
13 Zhao L, Chen S, Yang P, et al. The role of mesenchymal stem cells in hematopoietic stem cell transplantation: prevention and treatment of graft-versus-host disease. Stem Cell Research & Therapy. 2019; 10: 182 https://stemcellres.biomedcentral.com/articles/10.1186/s13287-019-1287-9
14 Clinical trials .Gov Website. Last accessed September 25, 2019 https://clinicaltrials.gov/ct2/results?cond=diabetes+mesenchymal+stem+cells&Search=Apply&recrs=b&recrs=a&recrs=f&recrs=d&recrs=e&age_v=&gndr=&type=&rslt=
15 Zhang Z, Fu J, Xu X, et al. Safety and immunological responses to human mesenchymal stem cell therapy in difficult-to-treat HIV-1-infected patients. AIDS. 2013; 27(8): 1283,1293 https://www.ncbi.nlm.nih.gov/pubmed/23925377
16 ClinicalTrials.org registry NCT01090817, NCT01157650, NCT01659762, NCT00294112, NCT00482092, NCT03901235, NCT03449069, NCT00543374, NCT03220243, NCT02445547. Last accessed September 25, 2019
22Afarid M, Sanie-Jahromi F. Mesenchymal Stem Cells and COVID-19: Cure, Prevention, and Vaccination. Stem Cells International 2021. 2021;0705:1-12
上皮幹細胞潛在的治療應用
- 上呼吸道疾病(例如:吸煙者的支氣管上皮的修復和再生)
- 表面潰瘍(糖尿病)
- 各種類型的燒傷1
- 皮膚創傷
- 皮膚傷口
- 皮膚表皮重建2
- 肝軟組織3
- 胰腺軟組織4
- 胃腸道軟組織5,6
眼睛7
- 角膜皮樣瘤
- 角膜不透明和疤痕
- 角膜潰瘍
- 乾眼症
- 缺乏角膜緣
- 眼睛受傷(例如:化學灼傷)
- 角膜緣幹細胞缺乏症
- 眼表疾病
- 黃斑部病變:
- 年齡相關性近視
- 斯塔加特黃斑營養不良
- 史蒂文斯約翰遜症候群引起的眼部損傷
- 翼狀胬肉
1 ClinicalTrials.org registry NCT02904941, NCT03162367, NCT00856934, NCT00832156,NCT02145130, NCT03227146, NCT03229564, NCT02948023, NCT04030754, NCT03754218, NCT01655407, NCT02947737, NCT02765737, NCT00548314, NCT02325843, NCT03048188, NCT03913481, NCT02779205, NCT03791710, NCT02577861, NCT03686449. Accessed June 28, 2023.
2 Huang L, Wong YP, Gu H, et al. Stem cell-like properties of human umbilical cord lining epithelial cells and the potential for epidermal reconstitution. Cytotherapy. 2011;13:14555. https://www.ncbi.nlm.nih.gov/pubmed/20735166
3Lim R, Hodge A, Moore G, et al. A Pilot Study Evaluating the Safety of Intravenously Administered Human Amnion Epithelial Cells for the Treatment of Hepatic Fibrosis. Front Pharmacol. 2017; 8:549.
4Lim RHG, Liew JXK, Wee A, et al. Safety Evaluation of Human Cord-Lining Epithelial Stem Cells Transplantation for Liver Regeneration in a Porcine Model. Cell Transplant. 2020 Jan-Dec; 29:963689719896559.
5Fujino A, Cuchimoto Y, Mori T, et al. Evaluation of safety and efficacy of autologous oral mucosa-derived epithelial cell sheet transplantation for prevention of anastomotic restenosis in congenital esophageal atresia and congenital esophageal stenosis. Stem Cell Res Ther. 2023; 14, 86.
6Kanetaka K, Eguchi S. Regenerative medicine for the upper gastrointestinal tract. Regenerative Therapy. 2020; 15, 129-137.
7 ClinicalTrials.org registry NCT00459290, NCT00841581, NCT03916679,NCT03687632,NCT03608293, NCT02586883, NCT01722656, NCT00003704, NCT00667641, NCT02573324, NCT01166763, NCT01376349, NCT00999531, NCT00335491, NCT03519178, NCT00291135, NCT01635231. Accessed June 28, 2023.
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