Clinical Trials Related to Cord Blood Medical Applications
Thanks to the advancement of biotechnology, At present, Hematopoietic stem cells or HSCs have been used to treat up to 113 diseases and Cord blood is a rich source of HSCs. The number of FDA regulated clinical trials related to cord blood medical applications is constantly on the rise each year5,6, including neurological diseases, autoimmune system damage, cardiovascular disease are the main three categories of it. It is believed the number of treatable diseases will keep growing in the future.
- Amyotrophic Lateral Sclerosis (ALS)
- Crohn’s Disease
- Type 1 Diabetes Mellitus
- Rheumatoid Arthritis
- Multiple Sclerosis (MS)
- Graft-versus-Host Disease (GvHD)
- Kidney plus stem cell transplant
- Support for Misc. Open Cardiac Surgery
- Hypoplastic Left Heart Syndrome (HLHS)
- Grow Vascular Graft
- Critical Limb Ischemia
- Compartment Syndrome (Battlefield Trauma)
- Ischemic Stroke
- Ischemic Heart Disease
- Myocardial Infarction
- Cerebral Palsy
- Hypoxic Ischemic Encephalopathy (HIE)
- Spinal Cord Injury (SCI)
- Hearing Loss
- Alveolar Cleft Palate Repair
- Knee Cartilage Repair
- Cerebral Adrenoleukodystrophy
- Fanconi Anemia
- Severe Combined Immunodeficiency (SCID)
- Cell Anemia
- Wiskott-Aldrich Syndrome
- Chronic Granulomatous Disease (X-linked)
- Metachromatic Leukodystrophy
- Bronchopulmonary Dysplasia (BPD)
- Epidermolysis Bullosa
- Lysosomal Storage Diseases (in utero transplant)
Most Asked Questions by Parents Related to Cord Blood Banking
Under the circumstance of twins, it needs to bank the cord blood (or umbilical cord) varied. Twins can be categorized into two main types: Identical twins (monozygotic) when a single fertilized egg splits into two genetically identical havles and non-identical twins (dizygotic) where two eggs are fertilized at the same time. For identical twins, their cord blood can be combined for storage as the twins are genetically idential. But for non-identical twins, as their genes are different, it is suggested to store their cord blood separately.
Until June 2016, up to 113 diseases had been treated with cord blood transplants5,6. They could be divided into 7 categories, namely: Leukemia, Lymphomas, other Disorders of Blood Cell Proliferation, Inherited Disorders of Immune System, Inherited Metabolic Disorders, other Cancers and others.
Detail about 113 treatable disease please refer to Diseases Treated by Cord Blood Transplantation.
Cord blood and umbilical blood contain two different stem cells which are widely adopted in different medical aspects. Cord blood is a rich source of HSCs which can create the blood and immune cells. Cancers, blood-related, immunity and metabolic diseases can be treated by cord blood. Umbilical cord is a rich source of MSCs which can create structural and connective tissues. Apart from minimizing GvHD in directed and unrelated allogeneic cord blood transplants, MSCs can apply to chronic illnesses treatment, regenerative medicines as well as organ and tissue engineering. Since cord blood and umbilical cord are rich sources of different types of stem cells, they may help to repair the body in different ways.
Stem cells will stop all physiological activities and remain dormant in -196℃ liquid nitrogen. Therefore, the stem cells can be permanently stored theoretically19. Professor Hal E. Broxmeyer (microbiology and immunology) is a pioneer who advocates of cord blood stem cells cryogenic storage. He proved that stem cells stored for years were still very regenerative, indicating that the stem cells stored in 1985 and 1986 could still be applied to patients for transplant33.
On the contrary, there is no factual basis for the claim of stem cells being able to store permanently under -135℃. Noted that using the vapor nitrogen storage system would cause temperature fluctuation upon stem cells storage and thawing and seriously affect the viability of all samples' stem cells.
Almost all public cord blood banks, including worldwide large blood banks, use liquid nitrogen for stem cells storage.
Entrusted by most parents in Hong Kong1, Healthbaby has a very comprehensive service coverage. Apart from the traditional liquid nitrogen storage plan, HealthBaby also pioneered to provide the advanced BioArchive® System. All storage plan of HealthBaby adopts the expensive liquid nitrogen as storage medium to provide the most stable tempertature for stem cell viability, providing the most quality umbilical cord and cord blood storage service.
To cater for different needs of clients, HealthBaby's cord blood and umbilical cord storage plan have very flexible and comprehensive service plan. Regarding cord blood plan, clients could select the storage plan base on the storage and processing system needs.
The umbilical cord and cord blood service fee already includes registration fee, processing fee and 18 years storage fee, no any additional charge during the contracted year. Extra discounted would be provided for registering both umbilical cord and cord blood storage plan. HealthBaby existing customers and other cord blood bank customers could also enjoy special offers. Please contact us for deatils and any enquiries.
For more details of cord blood service plan please refer to Service Plan.